CLINICAL UPDATES
from SpectraCell Laboratories, Inc.

November 2008 – Vol. 2008, Issue 11

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In This Issue….

• Vitamin E may slash lung cancer risk
• Science builds for L-carnitine and muscle aging
• Vitamins A and B2 reduce anemia in pregnant women
• CoQ10 levels may predict survival in heart disease
• Autism linked to vitamin D deficiency
• Levels of B vitamins predict cognitive decline
• Zinc works synergistically with vitamin A

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CLINICAL UPDATE – Vitamin E may slash lung cancer risk
Increasing intakes of vitamin E may decrease the risk of lung cancer by over 50%, according to a new study.
(International Journal of Cancer, September 2008)
(Nutrition Research, October 2008)
LINK to FULL STORY
LINK to ABSTRACT Dietary alpha-, beta-, gamma- and delta-tocopherols in lung cancer risk
LINK to ABSTRACT a-Tocopherol modulates human umbilical vein endothelial cell expression of Cu/Zn superoxide dismutase and catalase and lipid peroxidation

CLINICAL UPDATE – Science builds for L-carnitine and muscle aging
Supplementation with L-carnitine may restore natural losses of the nutrient that occur naturally with age, according to a new study with rats.
(Journal of Gerontology, October 2008)
(Phytomedicine, August 2008)
LINK to FULL STORY
LINK to ABSTRACT L-carnitine supplementation and physical exercise restore age-associated decline in some mitochondrial functions in the rat.
LINK to ABSTRACT Dietary L-carnitine supplementation improves bone mineral density by suppressing bone turnover in aged ovariectomized rats.

CLINICAL UPDATE – Vitamins A and B2 reduce anemia in pregnant women
After two months, adding retinol and riboflavin to iron and folic acid supplementation helped reduce anemia more than iron and folic acid alone
(Journal of Nutrition, October 2008)
LINK to ABSTRACT Retinol and riboflavin supplementation decreases the prevalence of anemia in Chinese pregnant women taking iron and folic acid supplements.

CLINICAL UPDATE – CoQ10 levels may predict survival in heart disease
Study showed coenzyme Q10 independently predicted mortality rates in patients with chronic heart failure
(Journal of the American College of Cardiology, October 2008)
LINK to ABSTRACT Coenzyme Q10 – An independent predictor of mortality in chronic heart failure

CLINICAL UPDATE – Autism linked to vitamin D deficiency
Researchers propose that vitamin D deficiency during gestation affects fetal brain development that can manifest clinically as autism
(Medical Hypotheses, October 2008)
LINK to ABSTRACT Autism and vitamin D.

CLINICAL UPDATE – Levels of B vitamins predict cognitive decline
Low levels of folate and vitamin B12 were independently associated with poor cognitive function in a Japanese cohort, even when homocysteine levels were not high, according to study
(Clinical Nutrition, October 2008)
LINK to ABSTRACT Raised homocysteine and low folate and vitamin B12 concentrations predict cognitive decline in community-dwelling older Japanese adults.

CLINICAL UPDATE – Zinc works synergistically with vitamin A
In a study of 387 men and women, long-term zinc supplementation increased levels of vitamin A, but did not affect folate or vitamin E levels
(European Journal of Clinical Nutrition, October 2008)
LINK to ABSTRACT Effect of zinc supplementation on vitamin status of middle-aged and older European adults: the ZENITH study.