CLINICAL UPDATES
from SpectraCell Laboratories, Inc.
Volume 2008 - Issue 08 - August 2008
In This Issue….
• Consensus panel recommends testing Lp-PLA2
• How much vitamin D do we need?
• Weekly folic acid supplementation works as well as daily
• Vitamin C and E protect early embryo cells
• Research emphasizes synergistic effect of antioxidants
• Decreases in folate may cause dementiaSpectraCell News….
• SpectraCell now offers Aspirin Response Testing™ Read more…
CLINICAL UPDATE – Consensus panel recommends testing Lp-PLA2
Recommendations based on NCEP ATPIII and AHA Guidelines suggest using Lp-PLA2 for diagnosing vascular inflammation to better identify patients at high risk
(American Journal of Cardiology, June 2008)
LINK to ABSTRACT Consensus panel recommendation for incorporating lipoprotein-associated phospholipase A2 testing into cardiovascular disease risk assessment guidelines.
CLINICAL UPDATE – How much vitamin D do we need?
Depending on baseline levels, recommended doses of vitamin D vary from 3800 IU to 5000 IU (95-125 microg/day), according to a recent study, although the current RDA is only about 200 IU per day
(American Journal of Clinical Nutrition, June 2008)
LINK to ABSTRACT Vitamin D intake to attain a desired serum 25-hydroxyvitamin D concentration
CLINICAL UPDATE – Weekly folic acid supplementation works as well as daily
The effects of folic acid supplementation on serum homocysteine concentrations were similar when administered weekly versus daily concludes researchers from a randomized, double-blind trial
(Journal of Nutrition, August 2008)
LINK to ABSTRACT Weekly may be as efficacious as daily folic acid supplementation in improving folate status and lowering serum homocysteine concentrations in Guatemalan women.
CLINICAL UPDATE – Vitamins C and E protect early embryo cells
Study shows that the antioxidants reduce mitochondrial damage in early embryonic cells and increase hCG (human chorionic gonadotropin) and progesterone concentrations
(Placenta, July 2008)
LINK to ABSTRACT Vitamins C and E inhibit apoptosis of cultured human term placenta trophoblast.
CLINICAL UPDATE – Research emphasizes synergistic effect of antioxidants
Review suggests that CoQ10 and Vitamin E should be studied in their various functional forms along with their metabolites to provide the most accurate picture of how they work in biological systems
(Biochemical Pharmacology, August 2008)
LINK to ABSTRACT Ubiquinone and tocopherol: dissimilar siblings.
CLINICAL UPDATE – Decreases in folate may cause dementia
Study shows that incident dementia is strongly associated with changes in folate status
(Journal of Neurology, Neurosurgery, and Psychiatry, August 2008)
LINK to ABSTRACT Changes in folate, vitamin B12 and homocysteine associated with incident dementia.
