CLINICAL UPDATES
from SpectraCell Laboratories, Inc.

Volume 2008, Issue 04 - April 2008

In This Issue….
• Genes play a role in choline deficiency
• Folate reduces chromosomal abnormalities in sperm
• Plant sterols reduce LDL cholesterol
• Study confirms Lp(a) as an independent risk factor for heart disease
• Clinical trial supports large dose of vitamin D
• CoQ10 may ease fatigue after exercise

---

CLINICAL UPDATE – Genes play a role in choline deficiency
Reduced folate intake decreases choline status, but only when specific polymorphisms are present
(Journal of Nutritional Biochemistry, March 2008)
LINK to ABSTRACT Folate intake and the MTHFR C677T genotype influence choline status in young Mexican American women

 

CLINICAL UPDATE – Folate reduces chromosomal abnormalities in sperm
Folate status is important to men as well as women prior to conception, study says
(Human Reproduction, March 2008)
LINK to NEWS STORY
LINK to ABSTRACT The association of folate, zinc and antioxidant intake with sperm aneuploidy in healthy non-smoking men

 

CLINICAL UPDATE – Plant sterols reduce LDL cholesterol
Epidemiological study shows that increased consumption of plant sterols reduce LDL cholesterol in women
(American Journal of Clinical Nutrition, April 2008)
LINK to ABSTRACT Inverse relation between dietary intake of naturally occurring plant sterols and serum cholesterol in northern Sweden

 

CLINICAL UPDATE – Study confirms Lp(a) as an independent risk factor for heart disease
Lp(a) is only weakly correlated with known risk factors so knowing levels is crucial for CHD prevention even in people without traditional risk factors
(Archives of Internal Medicine, March 2008)
LINK to ABSTRACT Lipoprotein(a) levels and risk of future coronary heart disease: large-scale prospective data

 

CLINICAL UPDATE – Clinical trial supports large dose of vitamin D
Single doses of 100,000 IU of cholecalciferol (vitamin D) was safe and effective in increasing the serum concentration of vitamin D’s more active form, calcidiol
(American Journal of Clinical Nutrition, March 2008)
LINK to ABSTRACT Pharmacokinetics of a single, large dose of cholecalciferol

 

CLINICAL UPDATE – CoQ10 may ease fatigue after exercise
Supplements of CoQ10 may boost physical performance and reduce feelings of tiredness associated with exercise
(Nutrition, April 2008)
LINK to NEWS STORY
LINK to ABSTRACT Antifatigue effects of coenzyme Q10 during physical fatigue