CLINICAL UPDATES
from SpectraCell Laboratories, Inc.

Volume 2008, Issue 03 - March 2008

In This Issue….

• Science stacks up for B vitamins and pregnancy
• LDL particles are better treatment target than LDL cholesterol
• Body mass index linked with cancer
• Common antioxidant helps prevent breast cancer
• Vitamin D and omega-3 protect children from diabetes
• Magnesium reduces risk of gallstones in men

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CLINICAL UPDATE –Science stacks up for B vitamins and pregnancy
Low maternal vitamin B12 levels may increase risk of congenital heart problems; Folic acid may help prevent premature birth and placental abruption
(Molecular Genetics and Metabolism, January 2008)
(American Journal of Epidemiology, January 2008)
(Society of Maternal-Fetal Medicine Annual Meeting Proceedings, January 2008)
LINK to ABSTRACT Genetic and lifestyle factors related to the periconception vitamin B12 status and congenital heart defects: A Dutch case-control study.
LINK to ABSTRACT Folic acid and multivitamin supplement use and risk of placental abruption: a population-based registry study
LINK to NEWS STORY Folic acid may help prevent premature birth

CLINICAL UPDATE – LDL particles are better treatment target than LDL cholesterol
Reliance on LDL cholesterol instead of LDL particle numbers can undermine LDL-lowering therapies
(Journal of Clinical Lipidology, February 2008)
LINK to ABSTRACT Differential response of cholesterol and particle measures of atherogenic lipoproteins to LDL-lowering therapy: implications for clinical practice

CLINICAL UPDATE – Body mass index linked with cancer
Increased BMI is strongly associated with various cancers, especially renal and esophageal cancer
(Lancet, February 2008)
LINK to ABSTRACT Body-mass index and incidence of cancer: a systematic review and meta-analysis of prospective observational studies

CLINICAL UPDATE – Common antioxidant helps prevent breast cancer
N-acetylcysteine inhibits estrogen-induced transformation of epithelial cells
(Journal of Steroid Biochemistry and Molecular Biology, March 2008)
LINK to ABSTRACT Reduction of estrogen-induced transformation of mouse mammary epithelial cells by N-acetylcysteine

CLINICAL UPDATE – Vitamin D and omega-3 protect children from diabetes
Meta-analysis indicates vitamin D supplements benefit children at high risk for diabetes
(Archives of Disease in Childhood, March 2008)
(Journal of the American Medical Association, September 2007)
LINK to NEWS STORY
LINK to ABSTRACT Vitamin D supplementation in early childhood and risk of type I diabetes: a systematic review of meta-analysis
LINK to ABSTRACT Omega-3 polyunsaturated fatty acid intake and islet autoimmunity in children at increased risk for type I diabetes

CLINICAL UPDATE – Magnesium reduces risk of gallstones in men
Protection may relate to dyslipidemia and insulin hypersecretion caused by magnesium deficiency
(American Journal of Gastroenterology, February 2008)
LINK to ABSTRACT Long-term effect of magnesium consumption on the risk of symptomatic gallstone disease among men.