CLINICAL UPDATES
from SpectraCell Laboratories, Inc.

Volume 2008, Issue 01 - January 2008

In this issue...

• Low Vitamin D Linked to Heart Disease
• Vitamin D2 and D3 May Be Equally Effective
• LDL Particle Number Predicts CVD Risk Better than LDL Cholesterol
• RLP Predicts Cardiovascular Events Better than LDL Cholesterol
• Zinc Helps Elderly Fight Pneumonia
• L-Carnitine Improves Cognitive Function in Elderly

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CLINICAL UPDATE – Low Vitamin D Linked to Heart Disease
New study suggests that low vitamin D levels may increase cardiovascular events such as heart attack, heart failure or stroke by 62%
(Circulation, January 2008)
(Current Opinion in Clinical Nutrition and Metabolic Care, January 2008)
Link to NEWS SUMMARY
LINK to ABSTRACT Vitamin D Deficiency and Risk of Cardiovascular Disease
LINK to ABSTRACT Vitamin D and cardiovascular disease risk

CLINICAL UPDATE – Vitamin D2 and D3 May Be Equally Effective
Challenging the view that vitamin D3 is more potent than D2, researchers have reported that both forms are equally effective at maintaining 25-hydroxyvitamin D status.
(Journal of Clinical Endocrinology and Metabolism, December 2007)
Link to NEWS SUMMARY
LINK to ABSTRACT Vitamin D is as effective as vitamin D3 in maintaining circulating concentrations of 25-Hydroxyvitamin D.
Link to FULL PAPER

CLINICAL UPDATE – LDL Particle Number Predicts CVD Risk Better than LDL Cholesterol
Results from Framingham Offspring Study suggest LDL-P as a goal of LDL management
(Journal of Clinical Lipidology, January 2008)
Link to ABSTRACT LDL particle number and risk of future cardiovascular disease in the Framingham Offspring Study—Implications for LDL management

CLINICAL UPDATE – RLP Predicts Cardiovascular Events Better than LDL Cholesterol
High levels of RLP (Remnant Lipoprotein) indicate risk even in cases without atherosclerosis
(Atherosclerosis, October 2007)
Link to ABSTRACT Plasma remnant-like lipoprotein particles or LDL-C as major pathologic factors in sudden cardiac death cases

CLINICAL UPDATE –Zinc Helps Elderly Fight Pneumonia
Nursing home study finds it can prevent or shorten the illness
(American Journal of Clinical Nutrition, October 2007)
Link to NEWS SUMMARY
Link to ABSTRACT Serum zinc and pneumonia in nursing home elderly

CLINICAL UPDATE L-Carnitine Improves Cognitive Function in Elderly
Randomized clinical trial shows L-carnitine reduces mental and physical fatigue in centenarians
(American Journal of Clinical Nutrition, December 2007)
Link to ABSTRACT L-Carnitine treatment reduces severity of physical and mental fatigue and increases cognitive functions in centenarians: a randomized and controlled clinical trial